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NCCN Clinical Practice Guidelines

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2 CINV pathways targeted

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Impact of CINV

Prevent CINV right from the start

  • Prevention in cycle 1 is associated with reduced incidence of CINV in subsequent cycles1

Compliance with antiemetic guidelines makes a significant difference in preventing CINV*2

  • Among the recommended options in the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), NK1 and 5-HT3 plus dexamethasone are suggested for HEC and MEC CINV prevention†3

Study results (N=1,295)2:

When Patients RECEIVED guideline-consistent CINV prophylaxis as compared to guideline-inconsistent CINV prophylaxis...

CINV can significantly affect patients and can lead to emergency room and hospital visits3,4

Fourteen percent of patients on HEC or MEC regimens visited the hospital due to CINV.4 Of those...
were inpatient admissions — the most common, and most costly, type of hospital visit for CINV4

CINV impacts patients

NCCN Clinical Practice Guidelines

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2 CINV pathways targeted

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References: 1. Cohen L, de Moor CA, Eisenberg P, Ming EE, Hu H. Chemotherapy-induced nausea and vomiting—incidence and impact on patient quality of life at community oncology settings. Support Care Cancer. 2007;15(5):497-503. 2. Gilmore JW, Peacock NW, Gu A, et al. Antiemetic guideline consistency and incidence of chemotherapy-induced nausea and vomiting in US community oncology practice: INSPIRE study. J Oncol Pract. 2014;10(1):68-74. 3. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Antiemesis V2.2017. © National Comprehensive Cancer Network, Inc. 2017. All rights reserved. Accessed May 11, 2017. To view the most recent and complete version of the guideline, go online to NCCN.org. 4. Burke TA, Wisniewski T, Ernst FR. Resource utilization and costs associated with chemotherapy-induced nausea and vomiting (CINV) following highly or moderately emetogenic chemotherapy administered in the US outpatient hospital setting. Support Care Cancer. 2011;19(1):131-140.