2 Key pathways impacted by 1 agent

The correlation between these pharmacological data and clinical efficacy has not been established.
Netupitant is a selective antagonist of substance P/NK1 receptors. As shown in in vitro and in vivo studies, netupitant inhibits substance P-mediated response1
  • Netupitant has a mean plasma half-life of approximately 80 hours
  • Netupitant demonstrated 92.5% NK1 receptor occupancy at 6 hours, with 76% occupancy at 96 hours
Palonosetron is a 5-HT3 receptor antagonist with a strong binding affinity for this receptor1
  • Oral palonosetron has a mean plasma half-life of approximately 48 hours