The importance of acting early to prevent CINV

4XS More Likley
Experiencing 1 CINV event during the 1st cycle of moderately or highly emetogenic chemotherapy makes CINV in subsequent cycles almost 4 times as likely1
A retrospective study of 10,586 patients receiving prophylactic antiemetics prior to single-day chemotherapy1
  • Odds ratio for developing CINV in subsequent cycles in patients receiving highly emetogenic chemotherapy: 3.70 (95% CI, 2.88-4.74), p<0.0001
  • Odds ratio for developing CINV in subsequent cycles in patients receiving moderately emetogenic chemotherapy: 3.77 (95% CI, 3.04-4.68), p<0.0001
Chemotherapy-­related and patient factors may elevate the risk of CINV1

Emetic risk is influenced by the1:

Risk Factors

For multiple-drug regimens, risk is presented based on drug with the highest emetic risk.2

CINV can occur within 24 hours (acute) or from 24 hours to 5 days (delayed) following administration.2,3

Patient risk factors may also impact CINV. These include3,4:

CINV=chemotherapy-induced nausea and vomiting.
CI=confidence interval.