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How Does Chemo-Induced Nausea and Vomiting (CINV) Happen?

When you receive chemo, two things may happen in your body:

  • A certain part of your brain is triggered
  • Certain areas of your esophagus, stomach, and small and large intestine are triggered

These triggers start a process that leads to chemotherapy-induced nausea and vomiting.

Nausea and vomiting diagram
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Medicines can be used to block this process to help prevent chemotherapy-induced nausea and vomiting.

Approved Use/Important Safety Considerations

Approved Use

AKYNZEO® is a prescription medicine called an "antiemetic." AKYNZEO is used in combination with the medicine dexamethasone in people to help prevent the nausea and vomiting that happens right away or later with certain anti-cancer medicines (chemotherapy).

It is not known if AKYNZEO is safe and effective in children under 18 years of age.


Important Safety Considerations

AKYNZEO may cause serious side effects, including:

  • allergic reactions, such as anaphylaxis. Get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction: hives, swollen face, trouble breathing, or chest pain.
  • serotonin syndrome which can happen with AKYNZEO particularly with certain other medicines such as anti-depressants and anti-migraine medicines and can lead to death. Stop taking AKYNZEO capsules and go to the nearest hospital emergency room right away if you get any of the following symptoms: agitation, hallucinations or other changes in mental status, dizziness, fast heartbeat, sweating, high body temperature, shaking (tremors), unsteady movements, muscle twitching (overactive reflexes), or seizures with or without nausea, vomiting, and diarrhea.

The most common side effects of AKYNZEO capsules and injection include: headache, weakness, fatigue, upset stomach, constipation, and skin redness.

These are not all the possible side effects of AKYNZEO. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Before you take or receive AKYNZEO, tell your doctor about all of your medical conditions, including if you:

  • have had an allergic reaction to palonosetron or another medicine for nausea or vomiting.
  • have liver problems.
  • have kidney problems.
  • are pregnant or breastfeeding or plan to become pregnant or breastfeed. AKYNZEO may harm your unborn baby. It is not known if AKYNZEO passes into breast milk and you should not take AKYNZEO if you are breastfeeding.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. AKYNZEO and certain other medicines can affect each other, causing serious side effects.


Only take AKYNZEO as prescribed by your doctor and read the Patient Information located at the end of the Prescribing Information. You can also read the full Prescribing Information that is written for health professionals.

Expand

Approved Use/Important Safety Considerations

Approved Use

AKYNZEO® is a prescription medicine called an "antiemetic." AKYNZEO is used in combination with the medicine dexamethasone in people to help prevent the nausea and vomiting that happens right away or later with certain anti-cancer medicines (chemotherapy).

It is not known if AKYNZEO is safe and effective in children under 18 years of age.


Important Safety Considerations

AKYNZEO may cause serious side effects, including:

  • allergic reactions, such as anaphylaxis. Get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction: hives, swollen face, trouble breathing, or chest pain.
  • serotonin syndrome which can happen with AKYNZEO particularly with certain other medicines such as anti-depressants and anti-migraine medicines and can lead to death. Stop taking AKYNZEO capsules and go to the nearest hospital emergency room right away if you get any of the following symptoms: agitation, hallucinations or other changes in mental status, dizziness, fast heartbeat, sweating, high body temperature, shaking (tremors), unsteady movements, muscle twitching (overactive reflexes), or seizures with or without nausea, vomiting, and diarrhea.

The most common side effects of AKYNZEO capsules and injection include: headache, weakness, fatigue, upset stomach, constipation, and skin redness.

These are not all the possible side effects of AKYNZEO. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Before you take or receive AKYNZEO, tell your doctor about all of your medical conditions, including if you:

  • have had an allergic reaction to palonosetron or another medicine for nausea or vomiting.
  • have liver problems.
  • have kidney problems.
  • are pregnant or breastfeeding or plan to become pregnant or breastfeed. AKYNZEO may harm your unborn baby. It is not known if AKYNZEO passes into breast milk and you should not take AKYNZEO if you are breastfeeding.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. AKYNZEO and certain other medicines can affect each other, causing serious side effects.


Only take AKYNZEO as prescribed by your doctor and read the Patient Information located at the end of the Prescribing Information. You can also read the full Prescribing Information that is written for health professionals.