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Am I at Risk?

Am I at Risk for Chemo-Related Nausea and Vomiting?

Risk factors for chemo-related nausea and vomiting are different for everyone.

Some people are more likely than others to have nausea and vomiting. Nausea and vomiting caused by chemo can happen for different reasons. Some of those reasons may include your individual risk factors, such as your age or medical history.

Your chemo medicines may be more likely to cause these effects, and different types of chemo are more likely than others to do this.

Here are some individual risk factors that may increase your risk of chemo-related nausea and vomiting:

Your type of chemo regimen

You are a woman

You had episodes of vomiting during pregnancy

You are younger than 50 years old

You have a history of motion sickness

You suffered nausea and vomiting during past chemo treatments

You don’t drink alcohol or drink it only occasionally

If any of these apply to you, it may be even more important to get treatment to prevent chemo-related nausea and vomiting.

Speak with your doctor about your options for stopping chemo-related nausea and vomiting before it starts.

Approved Use/Important Safety Considerations

AKYNZEO (netupitant and palonosetron) capsules/(fosnetupitant and palonosetron) for injection is a prescription medicine called an “antiemetic.” AKYNZEO is used in combination with the medicine dexamethasone in adults to help prevent the nausea and vomiting that happens right away or later with certain anti‑cancer medicines (chemotherapy).

It is not known if AKYNZEO is safe and effective in children under 18 years of age.

Important Safety Considerations

  • AKYNZEO may cause serious allergic reactions, such as anaphylaxis. Get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction: hives, swollen face, trouble breathing, or chest pain
  • Serotonin syndrome can happen with AKYNZEO particularly with certain other medicines such as anti‑depressants and anti‑migraine medicines and can be life‑threatening. Stop taking AKYNZEO capsules and go to the nearest hospital emergency room right away if you get any of the following symptoms: agitation, hallucinations or other changes in mental status, dizziness, fast heartbeat, sweating, low body temperature, shaking (tremors), unsteady movements, muscle twitching (overactive reflexes), or seizures with or without nausea, vomiting, and diarrhea
  • The most common side effects of AKYNZEO capsules and injection include: headache, weakness, fatigue, upset stomach, constipation, and skin redness
  • Tell your doctor or nurse about all your medical conditions including if you are taking other medications or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed

Only take AKYNZEO as prescribed by your doctor. For additional information about AKYNZEO, talk to your doctor or see the full Full Prescribing Information.

You may report side effects to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

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Approved Use/Important Safety Considerations

AKYNZEO (netupitant and palonosetron) capsules/(fosnetupitant and palonosetron) for injection is a prescription medicine called an “antiemetic.” AKYNZEO is used in combination with the medicine dexamethasone in adults to help prevent the nausea and vomiting that happens right away or later with certain anti‑cancer medicines (chemotherapy).

It is not known if AKYNZEO is safe and effective in children under 18 years of age.

Important Safety Considerations

  • AKYNZEO may cause serious allergic reactions, such as anaphylaxis. Get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction: hives, swollen face, trouble breathing, or chest pain
  • Serotonin syndrome can happen with AKYNZEO particularly with certain other medicines such as anti‑depressants and anti‑migraine medicines and can be life‑threatening. Stop taking AKYNZEO capsules and go to the nearest hospital emergency room right away if you get any of the following symptoms: agitation, hallucinations or other changes in mental status, dizziness, fast heartbeat, sweating, low body temperature, shaking (tremors), unsteady movements, muscle twitching (overactive reflexes), or seizures with or without nausea, vomiting, and diarrhea
  • The most common side effects of AKYNZEO capsules and injection include: headache, weakness, fatigue, upset stomach, constipation, and skin redness
  • Tell your doctor or nurse about all your medical conditions including if you are taking other medications or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed

Only take AKYNZEO as prescribed by your doctor. For additional information about AKYNZEO, talk to your doctor or see the full Full Prescribing Information.

You may report side effects to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.