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How AKYNZEO Works

How AKYNZEO Works

AKYNZEO is a prescription medicine that is used in people to help prevent the nausea and vomiting that happens right away (acute) or later (delayed) with certain chemo medicines.

AKYNZEO is a combination medicine. It contains two medicines: NETUPITANT and PALONOSETRON. These medicines are from two different classes. Two different classes means AKYNZEO works on two different pathways in your body to prevent nausea and vomiting.

Approved Use/Important Safety Considerations

AKYNZEO is a prescription medicine called an “antiemetic.” AKYNZEO is used in people to help prevent the nausea and vomiting that happens right away or later with certain anti-cancer medicines (chemotherapy).

It is not known if AKYNZEO is safe and effective in children under 18 years of age.

Important Safety Considerations

  • AKYNZEO may cause serious allergic reactions, such as anaphylaxis. Get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction to AKYNZEO: hives, swollen face, trouble breathing, or chest pain
  • Serotonin syndrome can happen with AKYNZEO particularly with certain other medicines such as anti‑depressants and anti‑migraine medicines and can be life‑threatening. Go to the nearest hospital emergency room right away if you get any of the following symptoms: agitation, hallucinations or other changes in mental status, dizziness, muscle twitching, or seizures
  • The most common side effects of AKYNZEO are headache, weakness, fatigue, upset stomach, constipation, and skin redness

For more about AKYNZEO, talk to your doctor or see the Full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

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Approved Use/Important Safety Considerations

AKYNZEO is a prescription medicine called an “antiemetic.” AKYNZEO is used in people to help prevent the nausea and vomiting that happens right away or later with certain anti-cancer medicines (chemotherapy).

It is not known if AKYNZEO is safe and effective in children under 18 years of age.

Important Safety Considerations

  • AKYNZEO may cause serious allergic reactions, such as anaphylaxis. Get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction to AKYNZEO: hives, swollen face, trouble breathing, or chest pain
  • Serotonin syndrome can happen with AKYNZEO particularly with certain other medicines such as anti‑depressants and anti‑migraine medicines and can be life‑threatening. Go to the nearest hospital emergency room right away if you get any of the following symptoms: agitation, hallucinations or other changes in mental status, dizziness, muscle twitching, or seizures
  • The most common side effects of AKYNZEO are headache, weakness, fatigue, upset stomach, constipation, and skin redness

For more about AKYNZEO, talk to your doctor or see the Full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.