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When to Take AKYNZEO

When to Take AKYNZEO

AKYNZEO is given by your doctor as a pill that is taken by mouth or as an intravenous injection before your treatment at the start of each chemo cycle.

If you are prescribed AKYNZEO for injection, it will be given to you about 30 minutes before your chemo treatment.

If you are prescribed the AKYNZEO pill, you will take it about 1 hour before your chemo treatment.

  • If you are going to an infusion center for your chemo treatment, you may need to bring your AKYNZEO pill with you
  • Your doctor will tell you exactly when to take your AKYNZEO pill
  • If you take too much AKYNZEO, call your doctor or go to the nearest emergency room right away

You can take AKYNZEO with or without food.

AKYNZEO is given with dexamethasone

Dexamethasone is a steroid that is used to treat inflammation, or swelling, in the body and is usually given with most antiemetics, including AKYNZEO.

  • When given with AKYNZEO, dexamethasone is usually taken by mouth
  • For patients receiving a highly emetogenic chemo medicine, the doctor may also prescribe dexamethasone for 3 days after receiving chemo treatment

Dosing recommendations

Type of chemo medicine Day of chemo
(day 1)
After chemo
(days 2-4)
Highly emetogenic AKYNZEO pill and dexamethasone 12 mg Dexamethasone
8 mg once a day
or
AKYNZEO injection and dexamethasone 12 mg Dexamethasone
8 mg once a day
Moderately emetogenic AKYNZEO pill and dexamethasone 12 mg

Before taking AKYNZEO, tell your doctor about all your medical conditions, including if you

  • have had an allergic reaction to palonosetron or another medication for nausea or vomiting
  • have liver or kidney problems
  • are pregnant or plan to become pregnant. It is not known if AKYNZEO will harm your unborn baby
  • are breastfeeding or plan to breastfeed. It is not known if AKYNZEO passes into your breast milk. You and your doctor should decide if you will take AKYNZEO or breastfeed. You should not do both

Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements as they might interact with AKYNZEO.

  • AKYNZEO can effect certain medications that are metabolized through the liver
  • In addition, certain medications, when taken with AKYNZEO may lead to a serious side effect known as serotonin syndrome. Serotonin syndrome can be fatal

Approved Use/Important Safety Considerations

AKYNZEO (netupitant and palonosetron) capsules/(fosnetupitant and palonosetron) for injection is a prescription medicine called an “antiemetic.” AKYNZEO is used in combination with the medicine dexamethasone in adults to help prevent the nausea and vomiting that happens right away or later with certain anti‑cancer medicines (chemotherapy).

It is not known if AKYNZEO is safe and effective in children under 18 years of age.

Important Safety Considerations

  • AKYNZEO may cause serious allergic reactions, such as anaphylaxis. Get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction: hives, swollen face, trouble breathing, or chest pain
  • Serotonin syndrome can happen with AKYNZEO particularly with certain other medicines such as anti‑depressants and anti‑migraine medicines and can be life‑threatening. Stop taking AKYNZEO capsules and go to the nearest hospital emergency room right away if you get any of the following symptoms: agitation, hallucinations or other changes in mental status, dizziness, fast heartbeat, sweating, low body temperature, shaking (tremors), unsteady movements, muscle twitching (overactive reflexes), or seizures with or without nausea, vomiting, and diarrhea
  • The most common side effects of AKYNZEO capsules and injection include: headache, weakness, fatigue, upset stomach, constipation, and skin redness
  • Tell your doctor or nurse about all your medical conditions including if you are taking other medications or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed

Only take AKYNZEO as prescribed by your doctor. For additional information about AKYNZEO, talk to your doctor or see the full Full Prescribing Information.

You may report side effects to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

Expand

Approved Use/Important Safety Considerations

AKYNZEO (netupitant and palonosetron) capsules/(fosnetupitant and palonosetron) for injection is a prescription medicine called an “antiemetic.” AKYNZEO is used in combination with the medicine dexamethasone in adults to help prevent the nausea and vomiting that happens right away or later with certain anti‑cancer medicines (chemotherapy).

It is not known if AKYNZEO is safe and effective in children under 18 years of age.

Important Safety Considerations

  • AKYNZEO may cause serious allergic reactions, such as anaphylaxis. Get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction: hives, swollen face, trouble breathing, or chest pain
  • Serotonin syndrome can happen with AKYNZEO particularly with certain other medicines such as anti‑depressants and anti‑migraine medicines and can be life‑threatening. Stop taking AKYNZEO capsules and go to the nearest hospital emergency room right away if you get any of the following symptoms: agitation, hallucinations or other changes in mental status, dizziness, fast heartbeat, sweating, low body temperature, shaking (tremors), unsteady movements, muscle twitching (overactive reflexes), or seizures with or without nausea, vomiting, and diarrhea
  • The most common side effects of AKYNZEO capsules and injection include: headache, weakness, fatigue, upset stomach, constipation, and skin redness
  • Tell your doctor or nurse about all your medical conditions including if you are taking other medications or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed

Only take AKYNZEO as prescribed by your doctor. For additional information about AKYNZEO, talk to your doctor or see the full Full Prescribing Information.

You may report side effects to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.