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What Types of Chemo Cause It?

What Types of Chemo Medicines Cause Nausea and Vomiting?

Some chemo medicines are more likely than others to cause nausea and vomiting. Chemo medicines are grouped according to how likely they are to cause nausea and vomiting.

  • The ones most likely to cause nausea and vomiting are called highly emetogenic (eh-MET-oh-JEN-ic)
  • Other chemo medicines that are less likely to cause these effects are considered moderately emetogenic

Emesis is a medical term for vomiting. Emetogenic refers to a medicine that causes nausea and vomiting.

When some chemo medicines are given in high doses, or when they are given together, they can make the nausea and vomiting worse.

Moderately and highly emetogenic medicines

Listed below are examples of highly and moderately emetogenic chemo medicines that are currently available. Additional therapies are continually being developed.

Some of these medicines may be given together according to a set schedule. You may hear this course of treatment referred to as a regimen. When certain chemo medicines are combined, they can raise the risk of nausea and vomiting.

Highly emetogenic chemotherapies
Anthracycline/cyclophosphamide combination
Carmustine
Cisplatin
Cyclophosphamide*
Dacarbazine
Hexamethylmelamine (oral)
Mechlorethamine
Procarbazine (oral)
Streptozocin
Carboplatin*
Doxorubicin*
Epirubicin*
Daunorubicin*
Moderately emetogenic chemotherapies
Bendamustine Carboplatin*
Clofarabine Cyclophosphamide*
Cytarabine Daunorubicin*
Doxorubicin* Epirubicin*
Idarubicin Ifosfamide
Irinotecan Oxaliplatin
Romidepsin Thiotepa
Trabectedin Bosutinib (oral)
Ceritinib (oral) Crizotinib (oral)
Cyclophosphamide (oral) Imatinib (oral)
Temozolomide (oral) Vinorelbine (oral)
Alemtuzumab

*The level of emetogenicity may increase or decrease according to dose or administration.

Common chemo medicines used in the treatment of lung and breast cancers

Two types of cancer that affect a lot of Americans are lung cancer and breast cancer. The chemo medicines used in treatment of these cancers are usually highly emetogenic. Listed here are some common chemo medicines used for these types of cancer.

Lung Cancer Breast Cancer
Carboplatin Cyclophosphamide (IV and oral)
Cisplatin Docetaxel
Docetaxel Doxorubicin
Etoposide Epirubicin
Gemcitabine 5-fluorouracil
Paclitaxel
Pemetrexed
Vinblastine
Vinorelbine

Ask your doctor if the chemotherapy prescribed for you is likely to cause nausea and vomiting.

Approved Use/Important Safety Considerations

AKYNZEO (netupitant and palonosetron) capsules/(fosnetupitant and palonosetron) for injection is a prescription medicine called an “antiemetic.” AKYNZEO is used in combination with the medicine dexamethasone in adults to help prevent the nausea and vomiting that happens right away or later with certain anti‑cancer medicines (chemotherapy).

It is not known if AKYNZEO is safe and effective in children under 18 years of age.

Important Safety Considerations

  • AKYNZEO may cause serious allergic reactions, such as anaphylaxis. Get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction: hives, swollen face, trouble breathing, or chest pain
  • Serotonin syndrome can happen with AKYNZEO particularly with certain other medicines such as anti‑depressants and anti‑migraine medicines and can be life‑threatening. Stop taking AKYNZEO capsules and go to the nearest hospital emergency room right away if you get any of the following symptoms: agitation, hallucinations or other changes in mental status, dizziness, fast heartbeat, sweating, low body temperature, shaking (tremors), unsteady movements, muscle twitching (overactive reflexes), or seizures with or without nausea, vomiting, and diarrhea
  • The most common side effects of AKYNZEO capsules and injection include: headache, weakness, fatigue, upset stomach, constipation, and skin redness
  • Tell your doctor or nurse about all your medical conditions including if you are taking other medications or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed

Only take AKYNZEO as prescribed by your doctor. For additional information about AKYNZEO, talk to your doctor or see the full Full Prescribing Information.

You may report side effects to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

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Approved Use/Important Safety Considerations

AKYNZEO (netupitant and palonosetron) capsules/(fosnetupitant and palonosetron) for injection is a prescription medicine called an “antiemetic.” AKYNZEO is used in combination with the medicine dexamethasone in adults to help prevent the nausea and vomiting that happens right away or later with certain anti‑cancer medicines (chemotherapy).

It is not known if AKYNZEO is safe and effective in children under 18 years of age.

Important Safety Considerations

  • AKYNZEO may cause serious allergic reactions, such as anaphylaxis. Get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction: hives, swollen face, trouble breathing, or chest pain
  • Serotonin syndrome can happen with AKYNZEO particularly with certain other medicines such as anti‑depressants and anti‑migraine medicines and can be life‑threatening. Stop taking AKYNZEO capsules and go to the nearest hospital emergency room right away if you get any of the following symptoms: agitation, hallucinations or other changes in mental status, dizziness, fast heartbeat, sweating, low body temperature, shaking (tremors), unsteady movements, muscle twitching (overactive reflexes), or seizures with or without nausea, vomiting, and diarrhea
  • The most common side effects of AKYNZEO capsules and injection include: headache, weakness, fatigue, upset stomach, constipation, and skin redness
  • Tell your doctor or nurse about all your medical conditions including if you are taking other medications or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed

Only take AKYNZEO as prescribed by your doctor. For additional information about AKYNZEO, talk to your doctor or see the full Full Prescribing Information.

You may report side effects to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.