5-day coverage with a single dose of AKYNZEO®, on Day 1

 

AKYNZEO injection, an IV solution given as a single infusion 30 minutes before chemotherapy1

(AKYNZEO for injection and AKYNZEO injection have not been studied for the prevention of nausea and vomiting associated with AC chemotherapy.)

Chemotherapy regimen Day 1 Days 2-4
HEC
(including cisplatin-based)
AKYNZEO
(1 vial, infused over 30 minutes starting 30 minutes before chemotherapy)
Dexamethasone 8 mg
(once daily)
Dexamethasone 12 mg
(30 minutes before chemotherapy)
  • Avoid use in patients with severe hepatic impairment, as well as severe renal impairment or end-stage renal disease
  • Avoid use in pregnancy, limited data is available, may cause fetal harm
  • May be taken with or without food

AKYNZEO injection helps streamline preparation1

  • No reconstitution required; ready to dilute
  • Compatible with IV dexamethasone, which can be added to AKYNZEO solution or infused simultaneously
  • No refrigeration required; stored at room temperature (20˚C to 25˚C/68˚F to 77˚F)
  • Remains stable at room temperature for up to 24 hours after dilution with or without the addition of IV dexamethasone
  • Contains no polysorbate 80, no preservatives, no soy, and no egg lecithin

Incompatibility of AKYNZEO for Injection and AKYNZEO Injection

  • AKYNZEO for injection and AKYNZEO injection are incompatible with any solution containing divalent cations (eg, calcium, magnesium), including Lactated Ringer's Injection and Hartmann's Solution
  • Limited data are available on the compatibility of AKYNZEO for injection and AKYNZEO injection with other intravenous substances, additives or other medications with the exception of intravenous dexamethasone sodium phosphate, and they should not be added to the AKYNZEO solution or infused simultaneously. If the same intravenous line is used for sequential infusion of several different drugs, flush the line before and after infusion of AKYNZEO solution with 0.9% Sodium Chloride Injection, USP

See Dosing for Oral Capsules


Preparation of AKYNZEO injection1

  1. STEP 1

    Before administration, inspect the solution for particulate matter and discoloration. Discard the vial if particulates and/or discoloration are observed.

  2. STEP 2

    Aseptically prepare an infusion vial or bag filled with 30 mL of 5% dextrose injection, USP or 0.9% sodium chloride injection, USP.

  3. STEP 3

    Aseptically withdraw the entire volume of solution from the AKYNZEO vial (20 mL) and transfer it into the infusion vial or bag containing 30 mL of fluid (either 5% dextrose injection, USP or 0.9% sodium chloride injection, USP) to yield a total volume of 50 mL.

  4. STEP 4

    Gently invert the vial or bag until complete dissolution.

  5. STEP 5

    Before administration, inspect the final diluted solution for particulate matter and discoloration. Discard the vial or bag if particulates and/or discoloration are observed.


Administration and storage1

  • Administer intravenous infusion over 30 minutes, starting 30 minutes before chemotherapy
  • Compatible with IV dexamethasone which can be added to AKYNZEO solution or infused simultaneously
  • At the end of the of the infusion, flush the infusion line with the same carrier solution to ensure complete drug administration
  • No refrigeration required; store at room temperature (20°C-25°C/68°F-77°F)
  • No reconstitution required; solution is ready to dilute and remains stable for up to 24 hours after dilution with or without the addition of IV dexamethasone

AKYNZEO oral, a single capsule taken with or without food 1 hour before chemotherapy1

AKYNZEO capsules can be taken with or without food.1

Chemotherapy regimen Day 1 Days 2-4
HEC
(including cisplatin-based)
AKYNZEO Dexamethasone 8 mg
(once daily)
Dexamethasone 12 mg
(30 minutes before chemotherapy)
AC and Non-HEC AKYNZEO  
Dexamethasone 12 mg
(30 minutes before chemotherapy)

  • AC=anthracycline-cyclophosphamide; CINV=chemotherapy-induced nausea and vomiting; HEC=highly emetogenic chemotherapy.