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Complete response in acute and delayed CINV

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Netupitant/palonosetron (AKYNZEO®) targets 2 pathways

Netupitant is a selective antagonist of substance P/NK1 receptors. As shown in in vitro and in vivo studies, netupitant inhibits substance P-mediated response1
  • Netupitant has a mean plasma half-life of approximately 80 hours
  • Netupitant demonstrated 92.5% NK1 receptor occupancy at 6 hours, with 76% occupancy at 96 hours

Palonosetron is a 5-HT3 receptor antagonist with a strong binding affinity for this receptor1
  • Oral palonosetron has a mean plasma half-life of approximately 48 hours

Complete response in acute and delayed CINV

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Reference: 1. AKYNZEO® (netupitant/palonosetron) capsules Full Prescribing Information.