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Safety profile in CINV patients

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One dose* for 5 days of CINV prevention

SEE DOSING

Recommendations and considerations for drug interactions1

DRUG INTERACTIONS WITH AKYNZEO®

Agents Interaction Exposure Recommendation/
consideration
Dexamethasone Yes
Dexamethasone
Lower dexamethasone dosage
Midazolam Yes
Midazolam
Potential effects should be considered
Chemotherapeutic agents metabolized by CYP3A4 Yes
Agent
Caution and careful monitoring
Strong CYP3A4 inducers Yes
AKYNZEO
Avoid use with AKYNZEO
Strong CYP3A4 inhibitors Yes
AKYNZEO
No dosage adjustment necessary
CYP3A4 substrates Yes
Agent
Avoid use with AKYNZEO for one week OR consider dose reduction
Serotonergic drugs Yes Potential for serotonin syndrome Caution and careful monitoring for symptoms of serotonin syndrome
Oral contraceptives No
CYP2C9 substrates
(eg, warfarin)
No

Safety profile in CINV patients

REVIEW NOW

One dose* for 5 days of CINV prevention

SEE DOSING
Reference: 1. AKYNZEO® (netupitant/palonosetron) capsules Full Prescribing Information.